martedì 23 agosto 2016

Cellule tumorali geniali ma insidiose: ingannano il sistema immunitario



Le cellule tumorali impediscono al  sistema immunitario di attaccare e quindi distruggere le cellule malate con l'individuazione dell'interruttore( PD-1) che spegne le nostre difese. Questo meccanismo  è stato scoperto grazie ad uno studio dell'Ospedale Pediatrico Bambino Gesù, condotto insieme al dipartimento di medicina sperimentale dell'Università di Genova e pubblicato sulla rivista scientifica Journal of Allergy and ClinicalImmunology.

identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

Silvia Pesce, Marco Greppi, Giovanna Tabellini, Fabio Rampinelli, Silvia Parolini, Daniel Olive, Lorenzo Moretta, Alessandro Moretta, and others

Publication stage: In Press Corrected Proof

Journal of Allergy and Clinical Immunology

Published online: May 27, 2016

''XProgrammed death 1 (PD-1) is an immunologic checkpoint that limits immune responses by delivering potent inhibitory signals to T cells on interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing to immune escape mechanisms. Therapeutic PD-1 blockade has been shown to mediate tumor eradication with impressive clinical results. Little is known about the expression/function of PD-1 on human natural killer (NK) cells.We sought to clarify whether human NK cells can express PD-1 and analyze their phenotypic/functional features .We have identified and characterized a novel subpopulation of human NK cells expressing high levels of PD-1. These cells have the phenotypic characteristics of fully mature NK cells and are increased in patients with ovarian carcinoma. They display low proliferative responses and impaired antitumor activity that can be partially restored by antibody-mediated disruption of PD-1/programmed death ligand interaction.''.........



continua nella pagina NOVITA' SCIENTIFICHE





Nessun commento:

Quanti siamo ?